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© 1996 Oxford University Press

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SHORT COMMUNICATION: TPA decreases the p53 response to benzo[a]pyrene-DNA adducts in vivo in mouse skin

Terhi Tapiainen, Kaisu Järvinen, Paavo Pääkkö 1, Nina Bjelogrlic and Kirsi Vähäkangas 2

Departments of Pharmacology and Toxicology, University of Oulu FIN-90220 Oulu, Finland
1Departments of Pathology, University of Oulu FIN-90220 Oulu, Finland

2To whom correspondence should be addressed

TPA, a well-known tumor promoter, decreased the response of nuclear P53 immunoreactivity to benzo[a]pyrene-7, 8-diol-9, 10-epoxide (BPDE)-DNA adducts in C57BL/6 mouse skin in vivo. A dose-dependent increase in both the level of BPDE-DNA adducts and nuclear p53 immunoreactivity was found in mice treated topically with 50–750 µg benzo[a]pyrene. Such a positive correlation between the adducts and p53 positivity was suggested by an earlier study. Since p53 probably functions in DNA damage control, interference by TPA with the p53 response could be a mechanism in TPA- induced tumor promotion. Whether such a mechanism is more general in tumor promotion deserves further study.


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