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© 1995 Oxford University Press

research-article

Endogenous formation of N-nitrosomorpholine in mice from 15NO2 by inhalation and morpholine by gavage

Ethard W. Van Stee, Richard A. Sloane 1, Jane Ellen Simmons 2, Michael P. Moorman 1 and Klaus D. Brunnemann 3

Rt 9 Box 432F, Chapel Hill, NC 27514
1National Institute of Environmental Health Sciences MD A2-02, P0 Box 12233, Research Tnangle Park, NC 27709
2Environmental Protection Agency MD 74, Research Triangle Park, NC 27711
3Nayor Dana Institute for Disease Prevention, American Health Foundation Dana Road, Valhalla, NY 10595. USA

Male CD-I mice were exposed to an nominal concentration of 20 p.p.m. of 15N-nitrogen dioxide (15NO2) for 6 h/day for 4 days and for 2 h on the day 5, and to 1 g morpholine/kg body wt by gavage daily for five consecutive days. N Nitrosomorphoilne (NMOR) was found in whole mice, stomachs, skins with hair, and remains. The sum of indi vidual tissue concentrations measured separately was 3421 ng/tissue, where the average skin weighed 4.3 g, the average stomach weighed 1.0 g and the average remains weighed 22.2 g. The average whole mouse weighed 27.7 g and contained a total of 3903 ng of NMOR. The concentration of NMOR was highest in the skin, next highest in the stomach, and lowest in the remains. However, the total quantity of NMOR per tissue, while highest in the skin (83%), was next highest in the remains (14.8%) and lowest in the stomach (2.2%). GC-MS analysis served to distinguish between the NMOR of 15NO2 origin and that of other origin. All of the NMOR in the whole mouse homogenates was identified as 15NMOR In the stomach 73% was identified as 14NMOR, representing 1.6% of the total NMOR in the mouse, and 27% as 15 representing 0.6% of the total 15NMOR in the mouse. N Nitrosamine formation in vivo is discussed as a possibly ongoing mammalian process.


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